The Frequency and Characteristics of Severe Liver-Related Adverse Events in Patients with Chronic Liver Diseases after Vaccination against Severe Acute Respiratory Syndrome Coronavirus 2: A Retrospective Study

Background: Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is recommended for patients with chronic liver diseases as the vaccine can prevent and/or reduce severity of SARS-CoV-2 infection. However, we have little information on often-reported liver-related adverse events (LrAEs) caused by mRNA vaccine. Methods: We retrospectively investigated frequency and details LrAEs changes in function tests diseases. Results: Among 431 diseases, 416 (96.5%) had received ≥ times. 345 included analysis, 6 (1.7%) LrAEs; 3 ascites, increases transaminases, 1 an increase total bilirubin. Multivariate analysis demonstrated that cirrhosis autoimmune disease were risk factors LrAEs. In contrast, reserve assessed Child–Pugh ALBI scores did not markedly change after vaccination despite a small transaminase levels. Conclusion: vaccines, which used most our patients, are safe but slightly increased